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HOPON Study
The main
objective of the trial is to determine the benefit of HBO in the prevention
of osteoradionecrosis (ORN) subsequent to a surgical procedure in the
irradiated mandible.
Experimental arm is Standard management plus HBO: Patients will undergo
20 HBO treatments prior to surgery followed by a further 10 daily HBO
treatments. For details of the standard management please visit the
HOPON webpage at: http://www.lctu.org.uk/trial/trials_open.asp?id=49
Sites involved will be awarded £200 for each patient who completes
the trial. For more information please contact Mr. Matthew Bickerstaff
(Trial Coordinator - oasis@liv.ac.uk)
or Mr. Richard Shaw (Chief Investigator - richard.shaw@liv.ac.uk)
Information
leaflet here.
HOLLT Study
HOLLT stands
for Hyperbaric Oxygen in Lower Limb Trauma. This is an international
multi-centre, randomised controlled medical research study which aims
to assess the benefit of hyperbaric oxygen therapy (HBO) in the acute
stages of managing severe lower leg injuries.
HOLLT is
an international multi-centre, randomised controlled trial which aims
to assess the benefit of providing hyperbaric oxygen therapy (HBO) during
the acute stages of management of severe lower leg injuries, as an adjunct
to normal trauma care. It is being conducted by an international network
of trauma centres with hyperbaric treatment facilities. The HOLLT Study
Coordinating Centre is within the Department of Epidemiology and Preventive
Medicine at Monash University, Melbourne, Australia. The study design
is based upon a pilot study previously undertaken by The Alfred Hyperbaric
Service which is located on the same campus.
The study
commenced enrolments at The Alfred Hospital in January 2007 and at five
other collaborating sites over the course of 2007. A number of additional
sites plan to join the collaboration over the course of 2008. The study
aims to enrol its target of 250 subjects over approximately 3 years
and follow up will continue for two years after the last enrolment.
At this stage, further collaborators are still being sought.
The Transport
Accident Commission has granted funding for the first 2.5 years of operation
of the Study Centre and Australia’s National Health and Medical
Research Council has recently granted a further five year of funding
to cover the full duration of follow up. This is a collaborative, investigator
led study however and most of the costs of enrolling patients at each
study site are dependent upon collaborators having local resources or
achieving local funding to enable participation.
Click here
to download the June 2010 HOLLT Newsletter
Principal
Investigator : Dr Ian Millar, The Alfred Hospital, Melbourne, Australia
Tel: +61
(0)3 9903 0926
Fax: +61 (0)3 9903 0576
Email: hollt@med.monash.edu.au
www.hollt.org
Sahlgrenska
University Hospital decompression illness study
"Does
decompression illness lead to release of protein markers for neuronal
damage into cerebrospinal fluid?"
Study design
The participants (n=20) will be consecutive recompression-treated DCI
patients at the Hyperbaric Medicine Centre at Sahlgrenska University
Hospital. All recompression-treated DCI patients routinely undergo echocardiography
to detect patent foramen ovale (PFO) that may increase the risk of serious
DCI. One week and three months after recompression treatment the participants
will undergo lumbar puncture for collection of cerebrospinal fluid (CSF).
The CSF will be analysed for protein markers of neuronal damage. Finally,
all results will be compared to those obtained from an age-matched healthy
control group of individuals (n=10) who do not dive but gets recompressed,
and another control group of healthy divers (n=10) one week after an
uncomplicated dive. Based on a previous study on amateur boxers among
whom we detected a 50% increase in mean tau concentration in CSF after
bout the participant number of 20 + 10 + 10 in each arm of this study
yields a power of >85% when calculated according to Altman.
This study
is seeking to expand it's subject numbers by participation of other
hyperbaric centers.
Please
contact Per Arnell at
Sahlgrenska
Universitetssjukhuset
Område Östra
Tele: +46-(0)31 - 343 60 22
Mob: +46-(0)709 - 439622
Fax: +46-(0)31 - 3434490
per.arnell@vgregion.se
PHYPODE Project
The PHYPODE
Marie Curie FP7-PEOPLE-2010-Initial Training Network program aims to
foster knowledge of decompression phenomena.
The objectives
of the project are as follows:
- Develop
an educational and research framework for cross-fertilization of research
activities focused on the physiopathology of decompression specifically
focusing on the formation of intravascular bubbles with their pathophysiological
and clinical consequences.
- Promote
exchanges of fellows in mixed industrial-academic Research & Development
trajectories, thereby giving young researchers opportunities to share
research techniques and resources, and jointly participate in courses,
seminars, workshops and congress.
- Widen
the career prospects of young researchers by embracing the whole chain
of research applied to decompression: epidemiological, clinical and
fundamental research, ground experimentation with professional divers
and applied research in industry for the management of decompression.
The project
began in January 2011 and will finish in 4 years at the end of 2014.
It unites academic partners, international not-for-profit associations,
hyperbaric medical centres and industrial partners on an international
scale to provide a collaborative training and research programme for
Early Stage (ESR) and Experienced (ER) researchers.
Additional information is available at http://www.phypode.org/
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